Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.61 |
| ▸ | CNOT7 | Q9UIV1 | 5/20 | 0.57 |
| ▸ | PARN | O95453 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988101 | 0.84 | CNOT7 (0.55) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7974027 | 0.84 | CNOT7 (0.57) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7975135 | 0.84 | CNOT7 (0.52) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7987472 | 0.83 | CNOT7 (0.54) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7985519 | 0.83 | CNOT7 (0.51) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7975271 | 0.83 | CNOT7 (0.56) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7985640 | 0.82 | CNOT7 (0.53) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7975254 | 0.82 | CNOT7 (0.55) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7987619 | 0.81 | CNOT7 (0.52) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 | |
| SCHEMBL7984663 | 0.81 | CNOT7 (0.49) | PNPCNOT7PARNSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049544-B9 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7863285-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| EP-2049544-B1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2010-11-03 | — | — | EP | disclosed |
| EP-2049544-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-03-19 | — | — | US | disclosed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| WO-2007150026-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | PNP 1193/4885CNOT7 3149/4885PARN 2151/4885 |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | PNP 1193/4885CNOT7 3149/4885PARN 2151/4885 |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | PNP 1193/4885CNOT7 3149/4885PARN 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.