Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PCK1 | P35558 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712900 | 0.87 | ADORA2B (0.41) | ADORA2AADORA3ADORA2BADORA1PCK1 | |
| SCHEMBL1713216 | 0.85 | ADORA2B (0.43) | ADORA2AADORA3ADORA2BADORA1PCK1 | |
| SCHEMBL1713194 | 0.85 | ADORA2A (0.40) | ADORA2AADORA3ADORA2BADORA1PCK1 | |
| SCHEMBL1712814 | 0.83 | ADORA3 (0.46) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| SCHEMBL1713057 | 0.79 | ADORA2B (0.40) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL1713205 | 0.78 | ADORA2A (0.36) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL1712679 | 0.76 | CDC7 (0.41) | ADORA2AADORA3ADORA2BALDH1A1KDM4E | |
| SCHEMBL1712833 | 0.76 | ADORA2A (0.40) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL1713342 | 0.75 | ADORA2B (0.37) | ADORA2B | |
| SCHEMBL1713158 | 0.75 | ADORA2A (0.48) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049544-B9 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2011-07-20 | — | — | EP | claimed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | claimed |
| EP-2049544-B1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2010-11-03 | — | — | EP | claimed |
| EP-2049544-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-22 | — | — | EP | claimed |
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-04-02 | — | — | US | claimed |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2009-03-19 | — | — | US | claimed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | claimed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | claimed |
| WO-2007150026-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | claimed |
| EP-2049544-B9 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2049544-B9 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORP (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902205-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | disclosed |
| US-7462624-B2 | Purinone derivatives as HM74a agonists | INCYTE CORPORATION (US) | 2008-12-09 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| WO-2007150026-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088446-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA3 49/4885ADORA2B 68/4885 |
| US-20090076269-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA3 49/4885ADORA2B 68/4885 |
| US-20080045555-A1 | PURINONE DERIVATIVES AS HM74A AGONISTS | GPR84, P2RY1, ADRA1A | ADORA2A 12/4885ADORA3 49/4885ADORA2B 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.