Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278785 | 0.80 | KCNH2 (0.37) | MAPTKDM4EALDH1A1GAAPOLB | |
| SCHEMBL1714163 | 0.78 | FYN (0.47) | MAPTSMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL13402543 | 0.76 | KCNH2 (0.35) | MAPTKDM4EALDH1A1GAAPOLB | |
| SCHEMBL13402306 | 0.76 | KCNH2 (0.35) | MAPTKDM4EALDH1A1GAAPOLB | |
| SCHEMBL22191720 | 0.74 | MAPT (0.63) | MAPTL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1714099 | 0.73 | ALPL (0.48) | MAPTSMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL308600 | 0.73 | RECQL (0.48) | MAPTKDM4EALDH1A1GAAPOLB | |
| SCHEMBL4143234 | 0.72 | MAPK1 (0.46) | ALDH1A1GAAKMT2AMAPK1 | |
| SCHEMBL4148520 | 0.72 | MEN1 (0.48) | MAPTMEN1KMT2AKCNH2 | |
| SCHEMBL22191439 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186476-A | Tryptophan hydroxylase inhibitors and methods of their use | LEXICON PHARMACEUTICALS INC | 2011-09-14 | — | — | CN | disclosed |
| EP-2344160-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
| WO-2010039957-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | TPH1, TPH2, HNMT | MAPT 1941/4885L3MBTL1 1959/4885SMN1; SMN2 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.