Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HEXA | P06865 | 2/20 | 0.33 |
| ▸ | HEXB | P07686 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19751556 | 0.77 | MEN1 (0.38) | CA12CA9DAOMEN1KMT2A | |
| SCHEMBL9367162 | 0.77 | CA12 (0.50) | CA12CA9DAOMEN1KMT2A | |
| SCHEMBL3730907 | 0.69 | HTR2A (0.39) | CA9DAOCA1CA2KDM4E | |
| SCHEMBL28844727 | 0.68 | CCR2 (0.51) | DAOKDM4EALDH1A1FABP4 | |
| SCHEMBL9432618 | 0.68 | SRC (0.40) | CA12CA9HTR1A | |
| SCHEMBL10967544 | 0.68 | CA12 (0.41) | CA12CA9MEN1KMT2ABRD4 | |
| SCHEMBL1055201 | 0.67 | CA12 (0.57) | CA12CA9DAOMEN1KMT2A | |
| SCHEMBL9577060 | 0.61 | PARP1 (0.46) | DAOKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL23346692 | 0.61 | BRPF1 (0.50) | CA12CA9MEN1KMT2ABRD4 | |
| SCHEMBL2625811 | 0.61 | CDK4 (0.41) | DAOFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994005-B9 | TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma AG (DE) | 2012-01-11 | — | — | EP | disclosed |
| EP-1994005-B1 | TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | BAYER SCHERING PHARMA AG (DE) | 2011-07-20 | — | — | EP | disclosed |