Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171471 | 0.90 | BTK (0.67) | BTKKITSRCFLT3ITK | |
| SCHEMBL171445 | 0.80 | BTK (0.48) | BTKKITSRCFLT3ITK | |
| SCHEMBL13894283 | 0.80 | BTK (0.53) | BTKKITSRCFLT3ITK | |
| SCHEMBL13894036 | 0.76 | ITK (0.54) | BTKKITSRCFLT3ITK | |
| SCHEMBL172002 | 0.74 | BTK (0.36) | BTKITKBMXSMN1; SMN2KDM4E | |
| SCHEMBL3870962 | 0.74 | BTK (0.70) | BTKKITSRCFLT3ITK | |
| SCHEMBL171444 | 0.73 | BTK (0.45) | BTKBMXRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL171935 | 0.72 | BTK (0.59) | BTKKITSRCFLT3ITK | |
| SCHEMBL1038341 | 0.71 | BTK (0.70) | BTK | |
| SCHEMBL3658579 | 0.71 | BTK (0.55) | BTKKITSRCFLT3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426109-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-07 | — | — | EP | disclosed |