SCHEMBL171446

SCHEMBL171446

O=C(NO)c1ccc(O)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 1.00
TOP1 P11387 3/20 0.64
TERT O14746 1/20 0.60
MAPT P10636 2/20 0.59
SNCA P37840 1/20 0.59
KDM4E B2RXH2 3/20 0.58
CA12 O43570 2/20 0.58
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
CA7 P43166 2/20 0.58
CA9 Q16790 2/20 0.58
CA14 Q9ULX7 2/20 0.58
GAA P10253 2/20 0.58
POLB P06746 1/20 0.58
CA4 P22748 1/20 0.58
CA6 P23280 1/20 0.58
PTGS2 P35354 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
EGLN2 Q96KS0 1/20 0.55
XDH P47989 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18346609 1.00 HDAC6 (1.00) HDAC6TOP1TERTMAPTSNCA
SCHEMBL4362534 0.84 HDAC6 (0.72) HDAC6TOP1TERTMAPTSNCA
SCHEMBL27828053 0.84 HDAC6 (0.72) HDAC6TOP1TERTMAPTSNCA
SCHEMBL5924546 0.81 HDAC6 (0.68) HDAC6TOP1KDM4EEGLN2HDAC1
SCHEMBL14880111 0.81 HDAC6 (0.68) HDAC6KDM4EEGLN2HDAC1HDAC2
SCHEMBL31472702 0.80 HDAC6 (0.67) HDAC6TOP1TERTMAPTSNCA
SCHEMBL9140722 0.80 HDAC6 (0.67) HDAC6TOP1TERTMAPTSNCA
SCHEMBL328702 0.80 HDAC6 (0.67) HDAC6TOP1TERTMAPTSNCA
SCHEMBL2664433 0.80 HDAC6 (0.67) HDAC6TOP1TERTMAPTSNCA
SCHEMBL5488163 0.79 HDAC6 (0.66) HDAC6KDM4ECA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017353-B1 THERAPEUTIC PROCESS FOR INHIBITING NF-KAPPA B ELFORD HOWARD L (US) 2012-03-07 EP claimed
US-8029815-B2 Methods for treating or preventing restenosis and other vascular proliferative disorders ELFORD HOWARD L 2011-10-04 US claimed
US-7977383-B2 Containing alkali ions, electrolytes, a buffer, polyol, saccharide and hydroxamic acid derivatives DR. FRANZ KOEHLER CHEMIE GMBH (DE) 2011-07-12 US claimed
CN-100448440-C Protective solution for preventing local ischemic damage FRANTZ KOLER DR CHEMICAL GMBH (DE) 2009-01-07 CN claimed
US-20080050414-A1 Methods For Treating Or Preventing Restenosis And Other Vascular Proliferative Disorders ELFORD HOWARD L 2008-02-28 US claimed
EP-1744761-A1 METHODS FOR TREATING OR PREVENTING RESTENOSIS AND OTHER VASCULAR PROLIFERATIVE DISORDERS Molecules for Health, Inc. (US) 2007-01-24 EP claimed
WO-2005115405-A1 METHODS FOR TREATING OR PREVENTING RESTENOSIS AND OTHER VASCULAR PROLIFERATIVE DISORDERS MOLECULES FOR HEALTH, INC. (US) 2005-12-08 WO claimed
US-6924308-B1 Therapeutic process for inhibiting NF-κB MOLECULES FOR HEALTH, INC. 2005-08-02 US claimed
EP-1017353-A4 THERAPEUTIC PROCESS FOR INHIBITING NF-KAPPA B ELFORD HOWARD L (US) 2005-02-23 EP claimed
US-20040228839-A1 Composition and methods for treatment of HIV infection AVRAMIS VASSILIOS I (US) 2004-11-18 US claimed
US-5366996-A Administering hydroxamic acids ELFORD HOWARD L (US) 1994-11-22 US claimed
US-5350770-A Administering hydroxy benzamide derivative ELFORD HOWARD L (US) 1994-09-27 US claimed
EP-0610444-A1 METHOD OF TREATING VIRAL DISEASES ELFORD, Howard L. (US) 1994-08-17 EP claimed
WO-1994002135-A1 THERAPEUTIC PROCESS FOR THE TREATMENT OF SEPTIC SHOCK ELFORD HOWARD L (US) 1994-02-03 WO claimed
WO-1993012782-A1 METHOD OF TREATING VIRAL DISEASES ELFORD HOWARD L (US) 1993-07-08 WO claimed
EP-0140958-B1 ONCOLYTIC DRUG COMBINATIONS ELFORD, Howard L. (US) 1989-12-20 EP claimed
EP-0140958-A4 ONCOLYTIC DRUG COMBINATIONS. ELFORD HOWARD L (US) 1985-09-02 EP claimed
EP-0140958-A1 ONCOLYTIC DRUG COMBINATIONS. ELFORD HOWARD L (US) 1985-05-15 EP claimed
WO-1984004246-A1 ONCOLYTIC DRUG COMBINATIONS ELFORD HOWARD L 1984-11-08 WO claimed
US-4394389-A ANTITUMOR AGENTS RIET BARTHOLOMEUS VAN T 1983-07-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080050414-A1 Methods For Treating Or Preventing Restenosis And Other Vascular Proliferative Disorders RRM2B, PCNA, RRM2 HDAC6 1927/4885TOP1 255/4885TERT 1608/4885
US-20040228839-A1 Composition and methods for treatment of HIV infection ASNS, RNASE1, RNASEH1 HDAC6 1365/4885TOP1 1277/4885TERT 1332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.