Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073643 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL1714532 | 1.00 | SLC6A4 (0.64) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| Hydrochloric Acid SCHEMBL2071435 | 0.99 | SLC6A2 (0.63) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| Hydrochloric Acid SCHEMBL2071436 | 0.99 | SLC6A2 (0.63) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| Iodide SCHEMBL2071566 | 0.99 | SLC6A2 (0.63) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| Iodide SCHEMBL2071562 | 0.99 | SLC6A2 (0.63) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2074104 | 0.93 | SLC6A4 (0.55) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2072912 | 0.92 | SLC6A4 (0.54) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2074376 | 0.91 | SLC6A4 (0.53) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2070997 | 0.91 | SLC6A4 (0.53) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| EP-1756054-B1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-03-31 | — | — | EP | disclosed |
| EP-1756054-B1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-03-31 | — | — | EP | disclosed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | disclosed |
| EP-1957454-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007062994-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| EP-1756054-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC | 2006-02-02 | — | — | US | disclosed |
| WO-2005118539-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | TPH1, HTR1A, HTR3A | SLC6A4 14/4885SLC6A2 9/4885CYP2D6 67/4885 |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | TPH1, TPH2, HTR1A | SLC6A4 27/4885SLC6A2 24/4885CYP2D6 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.