Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 3/20 | 0.51 |
| ▸ | CMA1 | P23946 | 2/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479280 | 0.86 | ALDH1A1 (0.59) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL10626074 | 0.84 | CRBN (0.55) | CRBNHDAC6AHRCMA1SMYD3 | |
| Hydrochloric Acid SCHEMBL6992917 | 0.84 | SMYD3 (0.52) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL12694461 | 0.82 | AHR (0.50) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL398818 | 0.81 | TDP2 (0.66) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL3194345 | 0.81 | SMYD3 (0.58) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL30760741 | 0.81 | SMYD3 (0.58) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL29713338 | 0.81 | TDP2 (0.66) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL24124675 | 0.80 | AHR (0.59) | CRBNHDAC6AHRCMA1SMYD3 | |
| SCHEMBL14521036 | 0.80 | CRBN (0.60) | CRBNHDAC6AHRCMA1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257648-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | AUSPEX PHARMACEUTICALS, INC. | 2016-09-08 | — | — | US | disclosed |
| US-20150284327-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284327-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | ABL1, ERBB2, LCK | CRBN 800/4885HDAC6 901/4885AHR 1107/4885 |
| US-20160257648-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | ABL1, ERBB2, LCK | CRBN 800/4885HDAC6 901/4885AHR 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.