Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.66 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.57 |
| ▸ | AHR | P35869 | 3/20 | 0.56 |
| ▸ | CMA1 | P23946 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713338 | 1.00 | TDP2 (0.66) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL30731586 | 0.88 | CRBN (0.69) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL28385255 | 0.87 | SRD5A2 (0.53) | TDP2SMYD3CRBNHTTALDH1A1 | |
| SCHEMBL30760741 | 0.86 | SMYD3 (0.58) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL3194345 | 0.86 | SMYD3 (0.58) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL688890 | 0.86 | TDP2 (0.61) | TDP2SMYD3AHRHTTGAA | |
| SCHEMBL24124675 | 0.84 | AHR (0.59) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL14521036 | 0.84 | CRBN (0.60) | TDP2SMYD3CRBNAHRCMA1 | |
| SCHEMBL1144991 | 0.84 | SMYD3 (0.59) | TDP2SMYD3CRBNHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL29528151 | 0.84 | SMYD3 (0.57) | TDP2SMYD3CRBNAHRCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118901-A | Oxindole derivative, preparation method thereof and application thereof in TRPA1 inhibitor direction | 中国人民解放军北部战区总医院 | 2024-12-13 | — | — | CN | claimed |
| EP-3710427-B1 | SYNTHESIS OF A 2-INDOLINONE DERIVATIVE KNOWN AS INTERMEDIATE FOR PREPARING NINTEDANIB | FERMION OY (FI) | 2023-03-08 | — | — | EP | claimed |
| EP-3426649-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Respivert Limited (GB) | 2019-01-16 | — | — | EP | claimed |
| EP-3394048-A1 | INDOLINONES COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES | Respivert Limited (GB) | 2018-10-31 | — | — | EP | claimed |
| WO-2017153748-A1 | INDOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2017-09-14 | — | — | WO | claimed |
| WO-2017109513-A1 | INDOLINONES COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES | RESPIVERT LIMITED (GB) | 2017-06-29 | — | — | WO | claimed |
| US-7030112-B2 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | claimed |
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | claimed |
| CN-1038640-A | Two ring carboxamide, its preparation methods and contain the pharmaceutical composition of this material | BOEHRINGER MANNHEIM GMBH (DE) | 1990-01-10 | — | — | CN | claimed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | claimed |
| US-12630487-B2 | Method for introducing deuterated lower alkyl into amine moiety of compound containing secondary amine | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2026-05-19 | — | — | US | disclosed |
| EP-3939954-B1 | METHOD FOR INTRODUCING DEUTERATED LOWER ALKYL INTO AMINE MOIETY OF COMPOUND CONTAINING SECONDARY AMINE | OTSUKA PHARMA CO LTD (JP) | 2025-07-23 | — | — | EP | disclosed |
| WO-2025093060-A1 | 3-(INDOLAMINO)METHYLENE INDOLINE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF | 徐诺药业(南京)有限公司 | 2025-05-08 | — | — | WO | disclosed |
| CN-119118901-A | Oxindole derivative, preparation method thereof and application thereof in TRPA1 inhibitor direction | 中国人民解放军北部战区总医院 | 2024-12-13 | — | — | CN | disclosed |
| US-20240207246-A1 | PHARMACEUTICAL COMPOSITION | KYOWA KIRIN CO., LTD. (JP) | 2024-06-27 | — | — | US | disclosed |
| EP-0809631-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996023770-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1996-08-08 | — | — | WO | disclosed |
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5019587-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-28 | — | — | US | disclosed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240207246-A1 | PHARMACEUTICAL COMPOSITION | EGFR, VEGFA, KDR | TDP2 4369/4885SMYD3 4826/4885CRBN 2070/4885 |
| US-12630487-B2 | Method for introducing deuterated lower alkyl into amine moiety of compound containing secondary amine | AZI2, ALKBH2, MGMT | TDP2 1219/4885SMYD3 61/4885CRBN 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.