Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144014 | 0.86 | ADORA3 (0.44) | ADORA3ADORA1ADORA2A | |
| SCHEMBL17150929 | 0.83 | KMT2A (0.52) | KMT2AL3MBTL1ADORA3ADORA1ADORA2A | |
| SCHEMBL19820499 | 0.79 | CHKA (0.56) | JAK1 | |
| SCHEMBL19820632 | 0.79 | CHKA (0.56) | JAK1 | |
| Bicarbonate SCHEMBL4432116 | 0.78 | LMNA (0.38) | ADORA3ADORA1ADORA2AALDH1A1LMNA | |
| SCHEMBL30884034 | 0.77 | CCNA2 (0.48) | KMT2AL3MBTL1JAK1CDK9 | |
| SCHEMBL17143823 | 0.77 | HCAR1 (0.45) | JAK1ALDH1A1LMNATP53MAPT | |
| SCHEMBL17144495 | 0.77 | HCAR1 (0.45) | JAK1ALDH1A1LMNATP53MAPT | |
| SCHEMBL17143824 | 0.77 | HCAR1 (0.45) | JAK1ALDH1A1LMNATP53MAPT | |
| SCHEMBL30677299 | 0.76 | HCAR1 (0.48) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015151006-A1 | SUBSTITUTED PURINE COMPOUNDS AS BTK INHIBITORS | LUPIN LIMITED (IN) | 2015-10-08 | — | — | WO | disclosed |