Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152234 | 0.80 | ALDH1A1 (0.48) | LMNAFPR3FPR2ALDH1A1NPSR1 | |
| SCHEMBL17152606 | 0.78 | MMP1 (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4997614 | 0.77 | LMNA (0.48) | LMNAFPR3FPR2ALDH1A1MEN1 | |
| SCHEMBL17152161 | 0.74 | KDM1A (0.31) | — | |
| SCHEMBL17152493 | 0.73 | MLYCD (0.33) | ALDH1A1 | |
| SCHEMBL14065568 | 0.73 | LMNA (0.52) | LMNAFPR3FPR2ALDH1A1MEN1 | |
| SCHEMBL12507020 | 0.73 | LMNA (0.52) | LMNAFPR3FPR2ALDH1A1MEN1 | |
| SCHEMBL17152577 | 0.71 | CA12 (0.36) | LMNA | |
| SCHEMBL12414328 | 0.71 | LMNA (0.51) | LMNAFPR3FPR2ALDH1A1MEN1 | |
| SCHEMBL17152507 | 0.71 | HPGD (0.36) | LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |