Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152457 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1GPR139 | |
| SCHEMBL17152485 | 0.80 | TGM2 (0.49) | ALDH1A1KDM4ECYP2C9CYP2C19KMT2A | |
| SCHEMBL17152514 | 0.78 | GAA (0.42) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL17152509 | 0.78 | HPGD (0.51) | HTTALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL7391823 | 0.77 | CACNA1B (0.52) | CYP3A4CYP2D6KMT2AMEN1 | |
| SCHEMBL16110714 | 0.75 | HTT (0.60) | HTTALDH1A1KDM4ELMNACYP3A4 | |
| SCHEMBL14893158 | 0.75 | HTT (0.60) | HTTALDH1A1KDM4ELMNACYP3A4 | |
| SCHEMBL7391206 | 0.74 | LMNA (0.48) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10157138 | 0.73 | HTT (0.54) | HTTALDH1A1KDM4ELMNACYP3A4 | |
| SCHEMBL7391159 | 0.72 | CACNA2D1 (0.49) | ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |