Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152538 | 0.83 | TGM2 (0.54) | TGM2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17152216 | 0.82 | MAPT (0.49) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL17152571 | 0.80 | HTT (0.50) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL17152509 | 0.80 | HPGD (0.51) | ALDH1A1MEN1KMT2AGAAPOLB | |
| SCHEMBL28108366 | 0.76 | TGM2 (0.59) | TGM2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7391823 | 0.74 | CACNA1B (0.52) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18421181 | 0.73 | HRH3 (0.45) | ALDH1A1KMT2AMAPTGAATP53 | |
| SCHEMBL17152412 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL5567507 | 0.72 | P2RY1 (0.41) | ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL17152443 | 0.72 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |