Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156195 | 0.83 | DHODH (0.43) | ENPP3ALPLENPP1XIAPLRRK2 | |
| SCHEMBL17156261 | 0.81 | DHODH (0.46) | ENPP3ALPLENPP1XIAPF10 | |
| SCHEMBL17156413 | 0.79 | LRRK2 (0.38) | LRRK2MAPTMEN1KMT2ALMNA | |
| SCHEMBL17156393 | 0.79 | LPAR2 (0.46) | LRRK2 | |
| SCHEMBL17156128 | 0.77 | LRRK2 (0.42) | ENPP3ALPLENPP1XIAPLRRK2 | |
| SCHEMBL17156120 | 0.76 | TRPA1 (0.40) | F10F2LRRK2MAPTMEN1 | |
| SCHEMBL17156216 | 0.76 | TTR (0.42) | ENPP3ALPLENPP1XIAPLRRK2 | |
| SCHEMBL17156354 | 0.73 | SLC5A1 (0.43) | — | |
| SCHEMBL104732 | 0.71 | HPGD (0.51) | MEN1KMT2ALMNAHTTSLC6A4 | |
| SCHEMBL3262839 | 0.67 | MAPT (0.49) | MAPTLMNAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |