Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ABAT | P80404 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156120 | 0.86 | TRPA1 (0.40) | DHODHSLC6A4ADRB3ADRA1DABAT | |
| SCHEMBL17156216 | 0.86 | TTR (0.42) | DHODHSLC6A4LRRK2TTRENPP3 | |
| SCHEMBL17156197 | 0.81 | ENPP3 (0.41) | SLC6A4LRRK2ENPP3ALPLENPP1 | |
| SCHEMBL17156195 | 0.79 | DHODH (0.43) | DHODHTMEM97LRRK2ENPP3ALPL | |
| SCHEMBL17156393 | 0.78 | LPAR2 (0.46) | LRRK2 | |
| SCHEMBL17156413 | 0.78 | LRRK2 (0.38) | LRRK2TTRHTR1AP2RX7 | |
| SCHEMBL17156128 | 0.73 | LRRK2 (0.42) | LRRK2ENPP3ALPLENPP1XIAP | |
| SCHEMBL17156262 | 0.70 | DHODH (0.47) | DHODHLRRK2TTRKDM4EP2RX7 | |
| SCHEMBL11916154 | 0.69 | SLC6A4 (0.40) | DHODHSLC6A4ADRB3ADRA1DABAT | |
| SCHEMBL17156369 | 0.69 | DHODH (0.75) | DHODHSLC6A4ADRB3ADRA1DABAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |