Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156197 | 0.77 | ENPP3 (0.41) | LRRK2LMNAMEN1MAPTKMT2A | |
| SCHEMBL17156195 | 0.76 | DHODH (0.43) | LRRK2LMNAMEN1MAPTKMT2A | |
| SCHEMBL3263313 | 0.75 | ALK (0.47) | LRRK2LMNATDP1ALKALDH1A1 | |
| SCHEMBL17156261 | 0.73 | DHODH (0.46) | LRRK2TDP1KDM4EENPP3ALPL | |
| SCHEMBL4946642 | 0.72 | CHRNB2 (0.51) | LMNATDP1MEN1KMT2AHTT | |
| SCHEMBL29854164 | 0.72 | CHRNB2 (0.51) | LMNATDP1MEN1KMT2AHTT | |
| SCHEMBL17156216 | 0.71 | TTR (0.42) | LRRK2LMNAMEN1MAPTKMT2A | |
| SCHEMBL17156120 | 0.69 | TRPA1 (0.40) | LRRK2LMNAMEN1MAPTKMT2A | |
| SCHEMBL30163333 | 0.68 | LMNA (0.60) | LMNATDP1LTA4HHTTKDM4E | |
| SCHEMBL17156393 | 0.67 | LPAR2 (0.46) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |