Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156256 | 0.84 | RAB9A (0.44) | KDM4ENPC1RAB9AALDH1A1HSD17B10 | |
| SCHEMBL9294526 | 0.82 | KDM4E (0.45) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL13495147 | 0.81 | NPC1 (0.67) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL17156379 | 0.81 | DHODH (0.44) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL17156194 | 0.80 | KDM4E (0.46) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6341120 | 0.75 | KDM4E (0.47) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12003383 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1FFAR4MAPTSMO | |
| SCHEMBL6341439 | 0.74 | KDM4E (0.48) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL122881 | 0.74 | ALDH1A1 (0.52) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL17156399 | 0.73 | DHODH (0.52) | NPC1RAB9AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |