Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950077 | 0.83 | GAA (0.52) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL16588368 | 0.82 | RAPGEF4 (0.54) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL17863893 | 0.81 | GAA (0.59) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL5082029 | 0.80 | DDX3X (0.62) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL17508316 | 0.78 | RAPGEF4 (0.57) | RAPGEF4GAAMEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL17508234 | 0.77 | RAPGEF4 (0.56) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL17506802 | 0.77 | RAPGEF4 (0.56) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL16588367 | 0.76 | RAPGEF4 (0.48) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL16588349 | 0.75 | RAPGEF4 (0.50) | RAPGEF4GAAMEN1MAPTKMT2A | |
| SCHEMBL3323396 | 0.75 | MAPT (0.51) | GAAMEN1MAPTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121687-B1 | TRICYCLIC AMINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2015-10-14 | — | — | EP | disclosed |