Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15417943 | 0.83 | HDAC11 (0.45) | ALDH1A1KMT2AMEN1HDAC11HTR1D | |
| SCHEMBL7001839 | 0.78 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL17766854 | 0.76 | ACHE (0.47) | ALDH1A1KMT2AMEN1HTR1DHTR1B | |
| SCHEMBL18031255 | 0.76 | CA12 (0.56) | ALDH1A1GAAMAPK1 | |
| SCHEMBL16545001 | 0.75 | MAPT (0.51) | ALDH1A1KMT2AMEN1HDAC11HPGD | |
| SCHEMBL16478498 | 0.74 | MAPT (0.50) | ALDH1A1KMT2AMEN1HPGDGAA | |
| SCHEMBL15435813 | 0.74 | KMT2A (0.45) | ALDH1A1KMT2AMEN1HDAC11L3MBTL1 | |
| SCHEMBL6487931 | 0.74 | CA12 (0.53) | ALDH1A1HDAC11HTR1DHTR1BHPGD | |
| SCHEMBL25289661 | 0.73 | HDAC11 (0.49) | ALDH1A1KMT2AMEN1HDAC11HTR1D | |
| SCHEMBL30506566 | 0.73 | HDAC11 (0.49) | ALDH1A1KMT2AMEN1HDAC11HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922628-A1 | CYTOTOXIC COMPOUNDS INHIBITING TUBULIN POLYMERISATION | Université Paris-Saclay (FR) | 2021-12-15 | — | — | EP | disclosed |
| EP-3129368-B1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NAT RECH SCIENT (FR) | 2021-09-22 | — | — | EP | disclosed |
| US-20170035761-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-02-09 | — | — | US | disclosed |
| US-20170035761-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-02-09 | — | — | US | disclosed |
| WO-2015155262-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170035761-A1 | CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN | TUBB1, TUBB, TUBB3 | ALDH1A1 2717/4885KMT2A 3531/4885MEN1 2504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.