Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17174318 | 0.89 | DRD1 (0.43) | CYP3A4CYP1A1CYP1B1CYP1A2DRD1 | |
| SCHEMBL15698767 | 0.81 | DRD1 (0.62) | CYP3A4CYP1A2DRD1CYP11B1CYP11B2 | |
| SCHEMBL20101686 | 0.80 | MAPT (0.69) | CYP3A4CYP1A1CYP1B1CYP1A2CYP11B1 | |
| SCHEMBL25493360 | 0.76 | IDO1 (0.45) | CYP3A4CYP1A2DRD1CYP11B1CYP11B2 | |
| SCHEMBL19390537 | 0.75 | DRD1 (0.58) | CYP3A4CYP1A2DRD1CYP11B1CYP11B2 | |
| SCHEMBL25625872 | 0.74 | CYP11B2 (0.53) | CYP3A4CYP1A2CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL4762859 | 0.74 | MAPK8 (0.40) | CYP3A4DRD1NPC1RAB9AALDH1A1 | |
| SCHEMBL17174268 | 0.73 | DRD1 (0.56) | CYP3A4CYP1A2DRD1CYP11B1CYP11B2 | |
| SCHEMBL26259332 | 0.72 | PDGFRB (0.48) | CYP3A4CYP1A1CYP1B1CYP1A2DRD1 | |
| SCHEMBL1204577 | 0.71 | CYP11B2 (0.60) | CYP3A4CYP1A2CYP11B1CYP11B2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER INC. (US) | 2017-06-15 | — | — | US | disclosed |
| US-9617275-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20150291625-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | PFIZER (US) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291625-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | ARRB1, ADRA1D, ADRB1 | CYP3A4 803/4885CYP1A1 203/4885CYP1B1 280/4885 |
| US-20170165270-A1 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands | ARRB1, DRD3, ADRB1 | CYP3A4 1438/4885CYP1A1 742/4885CYP1B1 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.