Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987437 | 0.81 | KDM4E (0.50) | KDM4ELMNAGAAL3MBTL1TDP1 | |
| SCHEMBL5885440 | 0.77 | ALDH1A1 (0.60) | MAPK14ADORA2AKDM4ELMNAL3MBTL1 | |
| SCHEMBL71619 | 0.76 | MAPK14 (0.81) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL29405271 | 0.76 | MAPK14 (0.81) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL29596631 | 0.74 | MAPK14 (0.78) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL27962380 | 0.74 | MAPK14 (0.78) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL29767839 | 0.74 | MAPK14 (0.78) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL28252524 | 0.74 | MAPK14 (0.78) | MAPK14MAPK10ADORA2AKDM4ELMNA | |
| SCHEMBL31070210 | 0.72 | KDM4E (0.64) | MAPK14MAPK10KDM4EL3MBTL1KMT2A | |
| SCHEMBL1302945 | 0.72 | MAPK14 (0.58) | MAPK14MAPK10KDM4EGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131881-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2017-02-22 | — | — | EP | disclosed |
| WO-2015161142-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-22 | — | — | WO | disclosed |