Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718698 | 0.91 | KDM4E (0.77) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL1718732 | 0.86 | ALDH1A1 (0.75) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL1718615 | 0.84 | KDM4E (0.68) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL1718870 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL1718891 | 0.80 | KDM4E (0.67) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL1718968 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL25969165 | 0.79 | OPRK1 (0.66) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL1718833 | 0.79 | KDM4E (1.00) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL1718190 | 0.78 | ALDH1A1 (0.71) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL4737183 | 0.77 | TP53 (0.80) | ALDH1A1KDM4EPOLBRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2008056176-A1 | PYRAZOLOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | SCOTTISH BIOMEDICAL LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |