Sugi Predict

Sugi Predict / Compounds / SCHEMBL1719092

SCHEMBL1719092

SCHEMBL1719092

NC(=O)c1ncc(C(F)(F)F)cc1Cl

nearest known ligand 0.73

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.73
▸ GLA P06280 1/20 0.61
▸ HPGD P15428 1/20 0.61
▸ GAA P10253 3/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ MEN1 O00255 2/20 0.57
▸ MAPT P10636 3/20 0.56
▸ PLAU P00749 1/20 0.55
▸ LMNA P02545 1/20 0.54
▸ RAB9A P51151 2/20 0.53
▸ NPSR1 Q6W5P4 1/20 0.52
▸ HTT P42858 1/20 0.51
▸ CYP1A2 P05177 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29827991 1.00 ALDH1A1 (0.73) ALDH1A1GLAHPGDGAAKMT2A
Butyramide SCHEMBL27747503 0.87 ALDH1A1 (0.57) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL286688 0.84 HPGD (0.68) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL5212382 0.84 ALDH1A1 (0.65) ALDH1A1GLAHPGDGAAKMT2A
Hydrochloric Acid SCHEMBL7691125 0.83 HPGD (0.66) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL707320 0.83 ALDH1A1 (0.63) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL18668549 0.82 ALDH1A1 (0.62) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL14834493 0.82 ALDH1A1 (0.62) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL30593608 0.82 ALDH1A1 (0.62) ALDH1A1GLAHPGDGAAKMT2A
SCHEMBL14861898 0.81 CFTR (0.55) ALDH1A1GLAHPGDGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150266822-A1 Amide Compounds, Compositions And Uses Thereof RENOVIS, INC. 2015-09-24 — — US claimed
EP-1506196-B1 PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2012-01-18 — — EP claimed
EP-2262766-A2 AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF Renovis, Inc. (US) 2010-12-22 — — EP claimed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 — — EP claimed
WO-2009110985-A2 AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF RENOVIS, INC. (US) 2009-09-11 — — WO claimed
CN-116874441-A Flexible aryl formamide derivative containing 1,2, 4-oxadiazole as well as preparation method and application thereof 贵州大学 2023-10-13 — — CN disclosed
US-11746091-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-09-05 — — US disclosed
CN-114805197-B Fluorinated pyridine acyl urea insecticide and acaricide 青岛科技大学 2023-07-11 — — CN disclosed
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain ARENA PHARMACEUTICALS, INC. 2023-02-02 — — US disclosed
CN-114805197-A Fluorine-containing pyridine acyl urea insecticide and acaricide 青岛科技大学 2022-07-29 — — CN disclosed
US-11214548-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2022-01-04 — — US disclosed
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-06-24 — — US disclosed
WO-2014134341-A1 PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2014-09-04 — — WO disclosed
WO-2014134341-A1 PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. (US) 2014-09-04 — — WO disclosed
US-20140249104-A1 PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. 2014-09-04 — — US disclosed
US-8778950-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2014-07-15 — — US disclosed
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2013-06-27 — — US disclosed
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2012-08-23 — — US disclosed
EP-2470508-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2012-07-04 — — EP disclosed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 ALDH1A1 3623/4885GLA 1547/4885HPGD 2679/4885
US-20140249104-A1 PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE BACE1, BACE2, APP ALDH1A1 170/4885GLA 657/4885HPGD 3538/4885
US-11746091-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 ALDH1A1 3623/4885GLA 1547/4885HPGD 2679/4885
US-11214548-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 ALDH1A1 3623/4885GLA 1547/4885HPGD 2679/4885
US-20150266822-A1 Amide Compounds, Compositions And Uses Thereof IL1B, ADORA2B, AVPR1B ALDH1A1 1016/4885GLA 715/4885HPGD 1641/4885
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain VIP, FABP2, FABP6 ALDH1A1 603/4885GLA 500/4885HPGD 210/4885
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 ALDH1A1 3623/4885GLA 1547/4885HPGD 2679/4885
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 ALDH1A1 3623/4885GLA 1547/4885HPGD 2679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.