Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718119 | 0.93 | THRB (0.59) | RXFP1THRBMAPTPOLBMEN1 | |
| SCHEMBL1718229 | 0.91 | MAPT (0.64) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1719731 | 0.90 | RXFP1 (0.61) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1718823 | 0.89 | MAPT (0.69) | RXFP1THRBMAPTPOLBMEN1 | |
| SCHEMBL1719614 | 0.88 | RXFP1 (0.63) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1719295 | 0.88 | RXFP1 (0.65) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1718538 | 0.87 | RXFP1 (0.68) | RXFP1MAPTUSP2MAPK1POLB | |
| SCHEMBL1719288 | 0.86 | RXFP1 (0.64) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1719926 | 0.86 | MAPT (0.67) | RXFP1THRBMAPTUSP2MAPK1 | |
| SCHEMBL1718203 | 0.86 | ALDH1A1 (0.61) | RXFP1THRBMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |