Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719219 | 0.83 | POLB (0.65) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| Benzylamine SCHEMBL1719444 | 0.77 | POLB (0.51) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| SCHEMBL3283065 | 0.73 | TDP1 (0.60) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| SCHEMBL1718373 | 0.65 | POLB (1.00) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| SCHEMBL1718847 | 0.64 | POLB (0.79) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| SCHEMBL27419910 | 0.64 | ALDH1A1 (0.53) | POLBTDP1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL23534262 | 0.64 | POLB (0.52) | POLBTDP1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL23534535 | 0.63 | TDP1 (0.51) | POLBTDP1SMN1; SMN2KDM4EAPOBEC3A | |
| SCHEMBL6429495 | 0.62 | THRB (0.48) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL11176841 | 0.62 | THRB (0.48) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |