Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18891292 | 0.89 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL23636525 | 0.86 | PSEN1 (0.32) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17192516 | 0.85 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL17192510 | 0.84 | RAB9A (0.34) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL20017277 | 0.82 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL18891293 | 0.82 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL23869750 | 0.81 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL18891296 | 0.81 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL21250290 | 0.78 | CCR2 (0.30) | NPC1RAB9ASMN1; SMN2HTTCCR2 | |
| SCHEMBL18891430 | 0.76 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143840-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2017-05-25 | — | — | US | disclosed |
| US-9421274-B2 | Bio-orthogonal drug activation | KONINKLIJKE PHILIPS N.V. (NL) | 2016-08-23 | — | — | US | disclosed |
| US-20160106859-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2016-04-21 | — | — | US | disclosed |
| US-20150344514-A1 | CHEMICALLY CLEAVABLE GROUP | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2015-12-03 | — | — | US | disclosed |
| US-20150297741-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143840-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | JMJD7, KIT, PAICS | NPC1 4317/4885RAB9A 1583/4885SMN1; SMN2 4604/4885 |
| US-20150344514-A1 | CHEMICALLY CLEAVABLE GROUP | SQLE, CTRL, ENO1 | NPC1 4177/4885RAB9A 4672/4885SMN1; SMN2 3734/4885 |
| US-20150297741-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | KIT, JMJD7, TPSB2 | NPC1 4231/4885RAB9A 2831/4885SMN1; SMN2 4344/4885 |
| US-20160106859-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | JMJD7, KIT, PAICS | NPC1 4317/4885RAB9A 1583/4885SMN1; SMN2 4604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.