Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799283 | 0.82 | KDM4C (0.37) | NAMPTKDM4CNTRK1JAK2CNR2 | |
| SCHEMBL805063 | 0.80 | KDM4C (0.36) | NAMPTKDM4CL3MBTL1NTRK1JAK2 | |
| SCHEMBL13193074 | 0.79 | HPGD (0.47) | P2RX7MAPK1TYK2ALDH1A1GAA | |
| SCHEMBL2989594 | 0.75 | KDM4E (0.50) | P2RX7SIRT3TDP1MAPK1TYK2 | |
| SCHEMBL30674829 | 0.73 | KDM4C (0.49) | SIRT3TDP1MAPK1TYK2KDM4C | |
| SCHEMBL24515808 | 0.72 | P2RX7 (0.51) | P2RX7SIRT3TDP1NAMPTMAPK1 | |
| SCHEMBL30064136 | 0.69 | SIRT3 (0.43) | SIRT3TDP1MAPK1TYK2KDM4C | |
| SCHEMBL24997725 | 0.69 | KDM5A (0.45) | SIRT3TDP1MAPK1TYK2KDM4C | |
| SCHEMBL1423953 | 0.69 | SIRT3 (0.43) | SIRT3TDP1MAPK1TYK2KDM4C | |
| SCHEMBL29467545 | 0.69 | ALDH1A1 (0.51) | SIRT3TDP1MAPK1TYK2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |