Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | XPO1 | O14980 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12299958 | 0.82 | PTGS1 (0.74) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthenol SCHEMBL51013 | 0.82 | PTGS1 (1.00) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL50436 | 0.79 | PTGS2 (1.00) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL29595542 | 0.79 | PTGS2 (1.00) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL17513161 | 0.79 | PTGS2 (1.00) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL27803504 | 0.79 | PTGS2 (0.92) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL27950752 | 0.78 | PTGS2 (0.97) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL27681201 | 0.78 | PTGS2 (0.97) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| Osthole SCHEMBL27659943 | 0.75 | PTGS2 (0.90) | PTGS1MAOAPTGS2ABCB1ALDH1A1 | |
| SCHEMBL24075636 | 0.72 | MAOA (0.78) | PTGS1MAOAPTGS2ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9393226-B2 | Use of osthole for treating focal segmental glomerulosclerosis | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2016-07-19 | — | — | US | disclosed |
| US-20150297560-A1 | USE OF OSTHOLE FOR TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297560-A1 | USE OF OSTHOLE FOR TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS | LOXL3, OSBPL3, FES | PTGS1 531/4885MAOA 1366/4885PTGS2 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.