Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718950 | 0.88 | TRPV1 (0.45) | CHRM3MGLLTRPV1ALDH1A1MEN1 | |
| SCHEMBL1718946 | 0.88 | TRPV1 (0.45) | CHRM3MGLLTRPV1ALDH1A1MEN1 | |
| SCHEMBL1085512 | 0.84 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 | |
| SCHEMBL1719100 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 | |
| SCHEMBL1085086 | 0.82 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 | |
| SCHEMBL1422490 | 0.81 | GRIN2B (0.43) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 | |
| SCHEMBL1085525 | 0.80 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 | |
| SCHEMBL1718938 | 0.80 | L3MBTL3 (0.44) | — | |
| SCHEMBL1719489 | 0.77 | ADAMTS7 (0.40) | MGLLALDH1A1HSD11B1CNR2 | |
| SCHEMBL1085318 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNA7CHRNA5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173735-B1 | IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-01-11 | — | — | EP | disclosed |
| US-7935707-B2 | Imidazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-03 | — | — | US | disclosed |