Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719101 | 0.84 | MGLL (0.39) | MGLLHCRTR1HCRTR2HSD11B1MBTD1 | |
| SCHEMBL1719488 | 0.77 | CHRNB2 (0.42) | MGLLALDH1A1HSD11B1CNR2 | |
| SCHEMBL1718938 | 0.76 | L3MBTL3 (0.44) | LMNAPOLBHPGD | |
| SCHEMBL1085181 | 0.73 | MBTD1 (0.44) | MBTD1 | |
| SCHEMBL28783710 | 0.72 | MGLL (0.40) | MGLLCYP2C9CYP2C19ADORA1LMNA | |
| SCHEMBL1718950 | 0.71 | TRPV1 (0.45) | MGLLALDH1A1ADORA1 | |
| SCHEMBL1718946 | 0.71 | TRPV1 (0.45) | MGLLALDH1A1ADORA1 | |
| SCHEMBL1719147 | 0.69 | SMN1; SMN2 (0.50) | CYP2C9CYP2C19ALDH1A1LMNAPOLB | |
| SCHEMBL1719974 | 0.67 | TRPV4 (0.43) | MBTD1 | |
| SCHEMBL1420772 | 0.67 | SLC6A3 (0.45) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173735-B1 | IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-01-11 | — | — | EP | disclosed |
| US-7935707-B2 | Imidazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-03 | — | — | US | disclosed |