Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201521 | 0.82 | ALDH1A1 (0.34) | ALDH1A1GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL17201604 | 0.82 | HDAC3 (0.44) | ALDH1A1HPGDKMT2AKDM4EMAPT | |
| SCHEMBL17201502 | 0.81 | CTSS (0.39) | ALDH1A1LMNARAB9AHDAC1 | |
| SCHEMBL17201629 | 0.81 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL14100232 | 0.73 | AAK1 (0.41) | ALDH1A1 | |
| SCHEMBL17201507 | 0.72 | ALDH1A1 (0.35) | ALDH1A1HPGDKDM4EMAPTRAB9A | |
| SCHEMBL8549434 | 0.72 | TSHR (0.44) | ALDH1A1HPGDLMNAGABRA1GABRG2 | |
| SCHEMBL17201531 | 0.68 | GRM6 (0.35) | ALDH1A1HPGDHDAC1 | |
| SCHEMBL16942053 | 0.68 | ALDH1A1 (0.39) | ALDH1A1HPGDLMNAKMT2AGABRA1 | |
| SCHEMBL17201516 | 0.68 | ERN1 (0.46) | ALDH1A1HPGDKMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725459-B2 | 3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I | GRUNENTHAL GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| EP-3140309-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | Grünenthal GmbH (DE) | 2017-03-15 | — | — | EP | disclosed |
| WO-2015161928-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | Grünenthal GmbH (DE) | 2015-10-29 | — | — | WO | disclosed |
| US-20150307507-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | Grünenthal GmbH (DE) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307507-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | CTSK, OPRK1, CAT | ALDH1A1 886/4885HPGD 614/4885LMNA 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.