Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL18490923 | 0.88 | EPHX2 (0.47) | EPHX2PTPN2PTPN1PTPN6ABL1 | |
| SCHEMBL17206298 | 0.87 | ATM (0.58) | MAPTATMALDH1A1NPC1MAPK1 | |
| SCHEMBL28425842 | 0.80 | PTPN2 (0.54) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| SCHEMBL17205899 | 0.80 | RXFP1 (0.53) | EPHX2MAPTALDH1A1 | |
| SCHEMBL17202971 | 0.77 | ATM (0.56) | EPHX2MAPTCD274ATMALDH1A1 | |
| SCHEMBL31752794 | 0.76 | SIGMAR1 (0.56) | — | |
| SCHEMBL17832684 | 0.76 | ALDH1A1 (0.73) | PTPN2PTPN1PTPN6ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL17202790 | 0.76 | ATM (0.55) | EPHX2MAPTCD274ATMALDH1A1 | |
| SCHEMBL31396747 | 0.75 | ABL1 (0.65) | EPHX2PTPN2PTPN1PTPN6ABL1 | |
| SCHEMBL2514655 | 0.75 | VEGFA (0.54) | MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134408-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015164308-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-29 | — | — | WO | disclosed |