Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411427 | 0.81 | CYP3A4 (0.42) | SMN1; SMN2LMNAALOX15TSHRMAPK1 | |
| SCHEMBL5736431 | 0.80 | THRA (0.35) | — | |
| SCHEMBL17200284 | 0.80 | SLC6A4 (0.40) | SLC6A4 | |
| SCHEMBL1934074 | 0.80 | MAOB (0.34) | ALOX15 | |
| SCHEMBL1461252 | 0.79 | MAPT (0.41) | MAPTALDH1A1 | |
| SCHEMBL282196 | 0.79 | ALDH1A1 (0.41) | LMNATSHRSTAT3MAPTALDH1A1 | |
| SCHEMBL23036593 | 0.78 | TDP1 (0.42) | ALOX15MAPK1NPC1RAB9AMAPT | |
| SCHEMBL5735681 | 0.77 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL31680206 | 0.76 | PARP1 (0.33) | MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL19641545 | 0.76 | PARP1 (0.33) | MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137469-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2019-10-09 | — | — | EP | disclosed |
| EP-3134405-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-3134405-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2019-08-28 | — | — | EP | disclosed |
| US-20180346477-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2018-12-06 | — | — | US | disclosed |
| US-10077272-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2018-09-18 | — | — | US | disclosed |
| US-20180072750-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180072750-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2018-03-15 | — | — | US | disclosed |
| US-9868744-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9868744-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9745317-B2 | Heterocyclic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170037053-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170037053-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170037053-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2017-02-09 | — | — | US | disclosed |
| WO-2015166366-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| WO-2015166366-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| WO-2015162518-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015162518-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10077272-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | DRD2, DRD1, DRD4 | HAO1 940/4885SMN1; SMN2 1446/4885LMNA 4162/4885 |
| US-20180072750-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | HAO1 940/4885SMN1; SMN2 1446/4885LMNA 4162/4885 |
| US-20170037053-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | HAO1 933/4885SMN1; SMN2 1517/4885LMNA 4304/4885 |
| US-20170044174-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | HAO1 1487/4885SMN1; SMN2 916/4885LMNA 3708/4885 |
| US-20180346477-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | HAO1 940/4885SMN1; SMN2 1446/4885LMNA 4162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.