Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18428478 | 0.79 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL282712 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHR | |
| SCHEMBL15154024 | 0.79 | TSHR (0.32) | TSHR | |
| SCHEMBL17205115 | 0.79 | HAO1 (0.44) | ALDH1A1LMNAMAPTSTAT3TSHR | |
| SCHEMBL3937179 | 0.78 | GABRA1 (0.32) | — | |
| SCHEMBL18471986 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL17557208 | 0.75 | MAPT (0.41) | ALDH1A1HPGDMAPT | |
| SCHEMBL4208648 | 0.75 | TP53 (0.35) | — | |
| SCHEMBL2411427 | 0.75 | CYP3A4 (0.42) | ALDH1A1LMNAHPGDMAPTTSHR | |
| SCHEMBL282124 | 0.75 | AKR1B1 (0.32) | ALDH1A1LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-B1 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20110218225-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-08 | — | — | US | disclosed |
| US-7947726-B2 | Non-steroidal ligands for the glucocorticoid receptor, and compositions thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-24 | — | — | US | disclosed |
| US-7829552-B2 | Phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20090137655-A1 | Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090118236-A1 | Novel Phosphorus-Containing Thyromimetics | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2009-05-07 | — | — | US | disclosed |
| US-7514419-B2 | Phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |
| US-20050054700-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-03-10 | — | — | US | disclosed |
| US-6831093-B2 | For selectively modulating the activation, repression, agonism and antagonism effects of the glucocorticoid receptor in a patient; for therapy and prophylaxis of obesity, diabetes, depression, neurodegeneration or an inflammatory disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-12-14 | — | — | US | disclosed |
| EP-1467730-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6777442-B2 | Diphenyl derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-17 | — | — | US | disclosed |
| EP-1370523-A1 | DIPHENYL DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-20030176478-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NIH-DEITR | 2003-09-18 | — | — | US | disclosed |
| WO-2003061651-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |
| US-20030105078-A1 | Diphenyl derivatives | BAYER AKTIENGESSELLSCHAFT (DE) | 2003-06-05 | — | — | US | disclosed |
| WO-2002072539-A1 | DIPHENYL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054700-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NR3C1, NR3C2, GCGR | ALDH1A1 3489/4885LMNA 3108/4885HPGD 836/4885 |
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | PYGL, THRA, THOP1 | ALDH1A1 4227/4885LMNA 3568/4885HPGD 1338/4885 |
| US-20090118236-A1 | Novel Phosphorus-Containing Thyromimetics | THRA, PYGL, THRB | ALDH1A1 4038/4885LMNA 4127/4885HPGD 1761/4885 |
| US-20110218225-A1 | NON-STEROIDAL LIGANDS FOR THE GLUCOCORTICOID RECEPTOR, COMPOSITIONS AND USES THEREOF | NR3C1, NR3C2, GCGR | ALDH1A1 3489/4885LMNA 3108/4885HPGD 836/4885 |
| US-20030176478-A1 | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof | NR3C1, NR3C2, GCGR | ALDH1A1 3489/4885LMNA 3108/4885HPGD 836/4885 |
| US-20090137655-A1 | Non-Steroidal Ligands for the Glucocorticoid Receptor, Compositions and Uses Thereof | NR3C1, NR3C2, GCGR | ALDH1A1 3489/4885LMNA 3108/4885HPGD 836/4885 |
| US-20030105078-A1 | Diphenyl derivatives | DPP4, DPP3, DPM1 | ALDH1A1 922/4885LMNA 1567/4885HPGD 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.