SCHEMBL17205220

SCHEMBL17205220

C=CC(C#N)n1ccc(=O)[nH]c1=O

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 3/20 0.38
▸ DDB1 Q16531 1/20 0.35
▸ PKM P14618 1/20 0.33
▸ POLB P06746 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL264019 0.75 CRBN (0.46) CRBNDDB1PKMPOLBHSD17B10
SCHEMBL3993881 0.70 CRBN (0.45) CRBNDDB1POLBHSD17B10
SCHEMBL9696657 0.66 SLC6A4 (0.37) —
SCHEMBL28299870 0.65 CRBN (0.50) CRBNDDB1PKMPOLBHSD17B10
SCHEMBL27411171 0.65 CRBN (0.50) CRBNDDB1PKMPOLBHSD17B10
SCHEMBL2990979 0.65 CRBN (0.50) CRBNDDB1PKMPOLBHSD17B10
SCHEMBL11980707 0.64 POLB (0.41) CRBNPKMPOLBHSD17B10
SCHEMBL7204552 0.64 CRBN (0.48) CRBNDDB1PKM
SCHEMBL9065010 0.62 CRBN (0.47) CRBNDDB1PKMPOLBHSD17B10
SCHEMBL28282616 0.61 CRBN (0.42) CRBNDDB1PKMPOLBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151685-A1 RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2024-07-18 — — WO disclosed
EP-3394093-A1 METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDES Modernatx, Inc. (US) 2018-10-31 — — EP disclosed
EP-3386484-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS ModernaTX, Inc. (US) 2018-10-17 — — EP disclosed
EP-3324979-A2 INFECTIOUS DISEASE VACCINES ModernaTX, Inc. (US) 2018-05-30 — — EP disclosed
WO-2017112943-A1 METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDES MODERNATX, INC. (US) 2017-06-29 — — WO disclosed
WO-2017099823-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS MODERNATX, INC. (US) 2017-06-15 — — WO disclosed
EP-3134131-A1 NUCLEIC ACID VACCINES ModernaTX, Inc. (US) 2017-03-01 — — EP disclosed
WO-2017019935-A1 MULTIMERIC MRNA MODERNATX, INC. (US) 2017-02-02 — — WO disclosed
WO-2015164674-A1 NUCLEIC ACID VACCINES MODERNA THERAPEUTICS, INC. (US) 2015-10-29 — — WO disclosed
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