Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721366 | 0.85 | FFAR4 (0.68) | NPC1RAB9APKMFFAR4CYP11B2 | |
| SCHEMBL1721253 | 0.75 | FFAR4 (0.60) | FFAR4CYP11B2FFAR1LMNAHTT | |
| SCHEMBL1721039 | 0.70 | FFAR4 (0.62) | NPC1RAB9AFFAR4CYP11B2FFAR1 | |
| SCHEMBL1720348 | 0.70 | FFAR4 (0.56) | FFAR4CYP11B2FFAR1LMNAHTT | |
| SCHEMBL28632326 | 0.70 | NPC1 (0.73) | NPC1RAB9APKMCYP11B2KDM4E | |
| SCHEMBL28883282 | 0.70 | NPC1 (0.68) | NPC1RAB9APKMCYP11B2KDM4E | |
| SCHEMBL28630259 | 0.69 | NPC1 (0.73) | NPC1RAB9APKMCYP11B2KDM4E | |
| SCHEMBL13113270 | 0.69 | NPC1 (0.53) | NPC1RAB9APKMCYP11B2KDM4E | |
| SCHEMBL1726319 | 0.68 | CYP11B2 (0.58) | NPC1RAB9APKMFFAR4CYP11B2 | |
| SCHEMBL17131794 | 0.68 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406248-B1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD KK (JP) | 2013-12-25 | — | — | EP | claimed |
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | claimed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | claimed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | claimed |
| EP-2406248-B1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | CBR3, OPRD1, CBR1 | NPC1 1178/4885RAB9A 2604/4885PKM 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.