Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408256 | 0.81 | PDGFRB (0.39) | KMT2AL3MBTL1MEN1RAB9ATDP1 | |
| SCHEMBL12211032 | 0.78 | CYP4F2 (0.38) | RAB9ATDP1HPGD | |
| SCHEMBL28544455 | 0.78 | HTR5A (0.33) | KMT2AMEN1TDP1 | |
| SCHEMBL26111488 | 0.72 | SCD (0.42) | — | |
| SCHEMBL29142210 | 0.72 | KMT2A (0.50) | KMT2AL3MBTL1MEN1RAB9ATDP1 | |
| SCHEMBL27030469 | 0.71 | HRH3 (0.35) | KMT2AL3MBTL1MEN1RAB9AHPGD | |
| SCHEMBL23851314 | 0.71 | HRH3 (0.39) | KMT2AMEN1TDP1SMN1; SMN2HTT | |
| SCHEMBL26113171 | 0.71 | REN (0.39) | KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL28800663 | 0.70 | KMT2A (0.41) | KMT2AL3MBTL1MEN1RAB9ATDP1 | |
| SCHEMBL16741222 | 0.70 | PKM (0.47) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174992-B2 | Heterobicyclic compounds | AMGEN INC. (US) | 2015-11-03 | — | — | US | disclosed |