Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463892 | 0.74 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL11772012 | 0.72 | CYP11B2 (0.56) | CYP11B2CYP11B1 | |
| SCHEMBL13727763 | 0.72 | CYP11B2 (0.60) | CYP11B2CYP11B1 | |
| SCHEMBL14779919 | 0.64 | SRD5A1 (0.46) | CYP11B2CYP11B1 | |
| SCHEMBL11771884 | 0.62 | CYP11B2 (0.43) | CYP11B2CYP11B1DRD4 | |
| SCHEMBL20177859 | 0.60 | ADRA1A (0.31) | — | |
| SCHEMBL15472248 | 0.60 | NPSR1 (0.30) | — | |
| SCHEMBL29375857 | 0.59 | HSD17B1 (0.33) | — | |
| SCHEMBL1727000 | 0.59 | HSD17B1 (0.33) | — | |
| SCHEMBL2883166 | 0.58 | GAA (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278093-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-03-08 | — | — | US | disclosed |
| US-9278093-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150306091-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150306091-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150306091-A1 | ALDOSTERONE SYNTHASE INHIBITORS | CYP21A2, HSD11B1, HSD11B2 | CYP11B2 6/4885CYP11B1 7/4885DRD4 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.