Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554171 | 0.92 | NR4A2 (0.54) | NR4A2FFAR1FFAR4ALDH1A1MAOB | |
| SCHEMBL28605553 | 0.85 | PARP10 (0.49) | FFAR1FFAR4ALDH1A1PARP14PARP10 | |
| SCHEMBL10566317 | 0.84 | FFAR4 (0.52) | NR4A2FFAR1FFAR4MAOBNPC1 | |
| SCHEMBL4449146 | 0.84 | NR4A2 (0.56) | NR4A2NPC1RAB9AMRGPRX4MAP4K4 | |
| SCHEMBL4215754 | 0.83 | NR4A2 (0.59) | NR4A2ALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL9127513 | 0.81 | MRGPRX4 (0.51) | NR4A2FFAR1FFAR4ALDH1A1MAOB | |
| SCHEMBL13870505 | 0.81 | TP53 (0.48) | NR4A2ALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL13870464 | 0.81 | MRGPRX4 (0.59) | NR4A2FFAR1FFAR4ALDH1A1NPC1 | |
| SCHEMBL13888691 | 0.81 | SRD5A2 (0.56) | NR4A2FFAR1FFAR4ALDH1A1PPARA | |
| SCHEMBL13939923 | 0.81 | RAB9A (0.59) | NR4A2FFAR1ALDH1A1PARP14PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227037-A | Monohalogen or methyl substituted 5-HT2B antagonists with increased activity | 北京生命科学研究所 | 2021-08-06 | — | — | CN | disclosed |
| CN-110698451-A | Substituted dibenzo [ b, e ] thio (oxy) heptacyclo-11 (6H) -ketone compound and preparation method thereof | 山东诚汇双达药业有限公司 | 2020-01-17 | — | — | CN | disclosed |
| EP-2406248-B1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD KK (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | CBR3, OPRD1, CBR1 | NR4A2 1090/4885FFAR1 2483/4885FFAR4 4244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.