Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.52 |
| ▸ | POLB | P06746 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 4/20 | 0.49 |
| ▸ | CASP7 | P55210 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17211731 | 0.90 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL17213438 | 0.85 | ALDH1A1 (0.62) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL7285789 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL17211686 | 0.74 | L3MBTL1 (0.44) | ALDH1A1KDM4EL3MBTL1KMT2A | |
| SCHEMBL13856452 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL7284485 | 0.68 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL17211691 | 0.66 | KDM4E (0.61) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL10586275 | 0.65 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL9195646 | 0.65 | ALDH1A1 (0.51) | ALDH1A1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL27991328 | 0.65 | KDM4E (0.56) | ALDH1A1KDM4EMAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CAMKK2 | ALDH1A1 4764/4885KDM4E 770/4885POLB 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.