Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 4/20 | 0.48 |
| ▸ | TDO2 | P48775 | 9/20 | 0.47 |
| ▸ | IDO1 | P14902 | 8/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458344 | 0.75 | TDO2 (0.60) | METTL3TDO2IDO1CYP2C9 | |
| SCHEMBL459215 | 0.72 | TDO2 (0.54) | METTL3TDO2IDO1FBP1CYP2C9 | |
| SCHEMBL31158048 | 0.70 | TDO2 (0.53) | METTL3TDO2IDO1FBP1 | |
| SCHEMBL459193 | 0.70 | TDO2 (0.53) | METTL3TDO2IDO1FBP1 | |
| SCHEMBL789058 | 0.69 | TMEM97 (0.47) | — | |
| SCHEMBL23115879 | 0.67 | ALDH1A1 (0.51) | METTL3TDO2IDO1 | |
| SCHEMBL470163 | 0.67 | TDO2 (0.50) | METTL3TDO2IDO1FBP1 | |
| SCHEMBL3996007 | 0.66 | KMT2A (0.49) | — | |
| SCHEMBL22499111 | 0.66 | METTL3 (1.00) | METTL3 | |
| SCHEMBL30291890 | 0.66 | METTL3 (1.00) | METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406255-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | Glaxo Group Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102958-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |