Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721091 | 0.84 | ADORA1 (0.43) | ADORA2BADORA1GRIN1GRIN2BTP53 | |
| SCHEMBL1720864 | 0.83 | ADORA2B (0.43) | ADORA2BADORA1MAPT | |
| SCHEMBL30891846 | 0.79 | ADORA1 (0.54) | ADORA2BADORA1 | |
| SCHEMBL1724286 | 0.79 | ADORA1 (0.54) | ADORA2BADORA1 | |
| SCHEMBL1720830 | 0.77 | ADORA1 (0.41) | ADORA2BADORA1EGLN1CXCR1 | |
| SCHEMBL1721175 | 0.71 | ADORA2B (0.44) | ADORA2BADORA1 | |
| SCHEMBL5547307 | 0.68 | ADORA2B (0.40) | ADORA2BADORA1EGLN1MAPT | |
| SCHEMBL1720580 | 0.64 | SCD (0.38) | ADORA2BADORA1GRIN1GRIN2B | |
| SCHEMBL1064770 | 0.64 | ADORA2B (0.64) | ADORA2BADORA1 | |
| SCHEMBL4410107 | 0.63 | ADORA2B (0.71) | ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |