Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRE | P78334 | 2/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721052 | 0.85 | GPR119 (0.44) | P2RY12GPR119FAAH | |
| SCHEMBL1721178 | 0.78 | NR1H2 (0.48) | GPR119 | |
| SCHEMBL19686595 | 0.74 | CHRNB2 (0.37) | CHRNB2CHRNA4GPR119PDE4BHDAC2 | |
| SCHEMBL19686575 | 0.74 | CHRNB2 (0.40) | CHRNB2CHRNA4GPR119PDE4BHDAC2 | |
| SCHEMBL609845 | 0.72 | CHRNB2 (0.37) | CHRNB2CHRNA4GPR119PDE4BHDAC2 | |
| SCHEMBL1721384 | 0.72 | PIK3CD (0.35) | GPR119PDE4BFAAH | |
| SCHEMBL1721381 | 0.72 | GPR119 (0.43) | GPR119PDE4BFAAH | |
| SCHEMBL14752960 | 0.71 | MAPT (0.39) | CHRNB2CHRNA4GPR119PDE4BHDAC2 | |
| SCHEMBL12206742 | 0.70 | HDAC2 (0.36) | CHRNB2CHRNA4GPR119PDE4BHDAC2 | |
| SCHEMBL10139547 | 0.70 | CHRNB2 (0.50) | CHRNB2CHRNA4GPR119PDE4BHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406256-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103335-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |