Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRND | Q07001 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18059009 | 0.93 | OPRM1 (0.51) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15145443 | 0.88 | OPRM1 (0.57) | PSMB5OPRM1OPRD1OPRK1CTSB | |
| SCHEMBL16485401 | 0.88 | CHRNB2 (0.62) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA1 | |
| SCHEMBL23380746 | 0.87 | OPRM1 (0.47) | PSMB5KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL10545669 | 0.86 | CHRNB2 (0.67) | KLKB1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8983313 | 0.85 | CTSB (0.62) | OPRM1OPRD1OPRK1CTSBMMP9 | |
| SCHEMBL12139728 | 0.85 | OPRM1 (0.53) | PSMB5OPRM1OPRD1OPRK1CTSB | |
| SCHEMBL8983297 | 0.85 | CTSB (0.62) | OPRM1OPRD1OPRK1CTSBMMP9 | |
| SCHEMBL342804 | 0.85 | REN (0.52) | PSMB5OPRM1OPRD1OPRK1CTSB | |
| SCHEMBL29727782 | 0.85 | REN (0.52) | PSMB5OPRM1OPRD1OPRK1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173956-B2 | METAP2 inhibitors and methods of treating obesity | SYNDEVRX, INC. (US) | 2015-11-03 | — | — | US | disclosed |