Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.82 |
| ▸ | MAPT | P10636 | 14/20 | 0.82 |
| ▸ | MEN1 | O00255 | 13/20 | 0.82 |
| ▸ | RECQL | P46063 | 10/20 | 0.82 |
| ▸ | POLB | P06746 | 10/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | BLM | P54132 | 7/20 | 0.82 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.82 |
| ▸ | THRB | P10828 | 5/20 | 0.82 |
| ▸ | ALPL | P05186 | 4/20 | 0.82 |
| ▸ | ALPI | P09923 | 2/20 | 0.82 |
| ▸ | ALPG | P10696 | 2/20 | 0.82 |
| ▸ | PKM | P14618 | 1/20 | 0.82 |
| ▸ | USP2 | O75604 | 9/20 | 0.56 |
| ▸ | APEX1 | P27695 | 6/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 3/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680241 | 0.90 | MEN1 (1.00) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL19419943 | 0.74 | MAPT (0.62) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL17229213 | 0.72 | MAPT (0.67) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL20272169 | 0.71 | MEN1 (0.45) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL26459002 | 0.71 | MAPT (1.00) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL20705619 | 0.71 | MEN1 (0.45) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL8172936 | 0.70 | MAPT (0.64) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL17833967 | 0.69 | MAPT (0.67) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL17834314 | 0.69 | MEN1 (0.63) | KMT2AMAPTMEN1RECQLPOLB | |
| SCHEMBL29354790 | 0.68 | MAPT (1.00) | KMT2AMAPTMEN1RECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000511-B2 | Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20150315211-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-20150315211-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | KMT2A 3471/4885MAPT 1762/4885MEN1 3416/4885 |
| US-10000511-B2 | Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders | MCL1, BCL2, BCL2L1 | KMT2A 2775/4885MAPT 3689/4885MEN1 3272/4885 |
| US-20150315211-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | MCL1, BCL2, BCL2L1 | KMT2A 2775/4885MAPT 3689/4885MEN1 3272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.