Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | POLB | P06746 | 9/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.64 |
| ▸ | USP2 | O75604 | 7/20 | 0.64 |
| ▸ | APEX1 | P27695 | 4/20 | 0.64 |
| ▸ | NSD2 | O96028 | 3/20 | 0.64 |
| ▸ | ALPL | P05186 | 3/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | RECQL | P46063 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181654 | 0.85 | KDR (0.69) | MAPTPOLBL3MBTL1APEX1MEN1 | |
| SCHEMBL8181657 | 0.85 | KDR (0.69) | MAPTPOLBL3MBTL1APEX1MEN1 | |
| SCHEMBL6886015 | 0.80 | MAPT (0.88) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL6885417 | 0.78 | MAPT (0.81) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL6885414 | 0.78 | MAPT (0.81) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL8181735 | 0.77 | AKR1B1 (0.73) | MAPTPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL26459002 | 0.77 | MAPT (1.00) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL17833967 | 0.74 | MAPT (0.67) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL5991599 | 0.74 | MEN1 (0.75) | MAPTPOLBL3MBTL1USP2APEX1 | |
| SCHEMBL8183010 | 0.74 | MEN1 (0.76) | MAPTL3MBTL1MEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |