Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723018 | 0.71 | NPSR1 (0.35) | GRM5P2RX7NPSR1 | |
| SCHEMBL2845682 | 0.67 | GRM5 (0.34) | GRM5MEN1KMT2ALMNAP2RX7 | |
| SCHEMBL2849167 | 0.62 | GRM5 (0.35) | GRM5MEN1KMT2ALMNAP2RX7 | |
| SCHEMBL1723074 | 0.62 | P2RX7 (0.36) | GRM5LMNAP2RX7L3MBTL1GAA | |
| SCHEMBL1303913 | 0.61 | CHRM1 (0.35) | GRM5MEN1KMT2ALMNAP2RX7 | |
| SCHEMBL3250915 | 0.58 | MARS1 (0.39) | GRM5LMNAP2RX7L3MBTL1ALDH1A1 | |
| SCHEMBL3728350 | 0.58 | KDM4E (0.44) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL20855539 | 0.58 | KMT2A (0.48) | MEN1KMT2ALMNAL3MBTL1NPC1 | |
| SCHEMBL165819 | 0.58 | NPC1 (0.57) | MEN1KMT2ALMNAL3MBTL1NPC1 | |
| SCHEMBL31711605 | 0.57 | CES2 (0.55) | KMT2AL3MBTL1NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344492-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010035221-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |