Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723076 | 0.71 | GRM5 (0.37) | NPSR1GRM5P2RX7 | |
| SCHEMBL2845682 | 0.69 | GRM5 (0.34) | NPSR1GRM5P2RX7 | |
| SCHEMBL2849167 | 0.65 | GRM5 (0.35) | GRM5P2RX7 | |
| SCHEMBL1723074 | 0.62 | P2RX7 (0.36) | GRM5P2RX7 | |
| SCHEMBL3728350 | 0.61 | KDM4E (0.44) | — | |
| SCHEMBL3250915 | 0.61 | MARS1 (0.39) | GRM5P2RX7 | |
| SCHEMBL1722408 | 0.59 | MARS1 (0.37) | P2RX7 | |
| SCHEMBL3328392 | 0.58 | CYP4F2 (0.44) | — | |
| SCHEMBL31711605 | 0.57 | CES2 (0.55) | — | |
| SCHEMBL2031215 | 0.56 | SMN1; SMN2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344492-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010035221-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |