SCHEMBL1723263

SCHEMBL1723263

Cc1cc(CC(=O)Nc2ccc(-c3cnccn3)cn2)cnc1-c1ccnc(F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
WNT3A P56704 17/20 1.00
PORCN Q9H237 2/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30109338 1.00 WNT3A (1.00) WNT3APORCN
SCHEMBL1725945 0.92 WNT3A (1.00) WNT3APORCN
Wnt-974 SCHEMBL29382356 0.91 WNT3A (1.00) WNT3APORCN
Wnt-974 SCHEMBL1723611 0.91 WNT3A (1.00) WNT3APORCN
Wnt-974 SCHEMBL29351311 0.91 WNT3A (1.00) WNT3APORCN
SCHEMBL12303049 0.90 WNT3A (0.84) WNT3APORCN
SCHEMBL1722487 0.89 WNT3A (0.80) WNT3APORCN
SCHEMBL1725381 0.88 WNT3A (1.00) WNT3APORCN
SCHEMBL1726002 0.86 WNT3A (1.00) WNT3APORCN
SCHEMBL1726039 0.85 WNT3A (1.00) WNT3APORCN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3693476-B1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2023-10-18 EP claimed
US-20210054466-A1 TUMOR BIOMARKERS AND USE THEREOF CUREGENIX CORPORATION 2021-02-25 US claimed
EP-3693476-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS Novartis AG (CH) 2020-08-12 EP claimed
EP-2820151-B1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2020-03-25 EP claimed
US-20190203301-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2019-07-04 US claimed
US-20180153884-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION 2018-06-07 US claimed
EP-3302467-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY Curegenix Corporation (US) 2018-04-11 EP claimed
US-20170306409-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2017-10-26 US claimed
WO-2016196218-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION (US) 2016-12-08 WO claimed
US-20160024587-A1 MARKERS ASSOCIATED WITH WNT INHIBITORS NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. 2016-01-28 US claimed
EP-2972372-A2 MARKERS ASSOCIATED WITH WNT INHIBITORS Novartis AG (CH) 2016-01-20 EP claimed
US-20150125857-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF Wnt SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2015-05-07 US claimed
EP-2820151-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS Novartis AG (CH) 2015-01-07 EP claimed
WO-2014141038-A2 MARKERS ASSOCIATED WITH WNT INHIBITORS IRM LLC (BM) 2014-09-18 WO claimed
US-8546396-B2 N-(hetero)aryl, 2-(hetero)aryl—substituted acetamides for use as Wnt signaling modulators IRM LLC (BM) 2013-10-01 US claimed
WO-2013130364-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2013-09-06 WO claimed
EP-2403832-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2012-01-11 EP claimed
US-20110237573-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2011-09-29 US claimed
WO-2010101849-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2010-09-10 WO claimed
EP-3693476-B1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2023-10-18 EP disclosed
US-20230201194-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION 2023-06-29 US disclosed
US-20210128553-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION 2021-05-06 US disclosed
US-20210054466-A1 TUMOR BIOMARKERS AND USE THEREOF CUREGENIX CORPORATION 2021-02-25 US disclosed
EP-3693476-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS Novartis AG (CH) 2020-08-12 EP disclosed
EP-2820151-B1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2020-03-25 EP disclosed
US-10422007-B2 Markers associated with Wnt inhibitors NOVARTIS AG (CH) 2019-09-24 US disclosed
US-20190203301-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2019-07-04 US disclosed
US-10251893-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators NOVARTIS AG (CH) 2019-04-09 US disclosed
US-10251893-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators NOVARTIS AG (CH) 2019-04-09 US disclosed
US-20180153884-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION 2018-06-07 US disclosed
EP-2972372-B1 MARKERS ASSOCIATED WITH WNT INHIBITORS NOVARTIS AG (CH) 2018-04-25 EP disclosed
EP-3302467-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY Curegenix Corporation (US) 2018-04-11 EP disclosed
US-20180000832-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2018-01-04 US disclosed
US-20180000832-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2018-01-04 US disclosed
US-20170306409-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2017-10-26 US disclosed
WO-2016196218-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY CUREGENIX CORPORATION (US) 2016-12-08 WO disclosed
US-20160082014-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2016-03-24 US disclosed
US-20160082014-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2016-03-24 US disclosed
US-20160082014-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2016-03-24 US disclosed
US-20160024587-A1 MARKERS ASSOCIATED WITH WNT INHIBITORS NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. 2016-01-28 US disclosed
EP-2972372-A2 MARKERS ASSOCIATED WITH WNT INHIBITORS Novartis AG (CH) 2016-01-20 EP disclosed
US-9238646-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators NOVARTIS AG (CH) 2016-01-19 US disclosed
US-9238646-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators NOVARTIS AG (CH) 2016-01-19 US disclosed
US-9238646-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators NOVARTIS AG (CH) 2016-01-19 US disclosed
WO-2015145388-A2 METHODS OF TREATING COLORECTAL CANCERS HARBORING UPSTREAM WNT PATHWAY MUTATIONS NOVARTIS AG (CH) 2015-10-01 WO disclosed
US-20150125857-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF Wnt SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2015-05-07 US disclosed
EP-2623493-B1 N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS NOVARTIS AG (CH) 2015-04-22 EP disclosed
EP-2820151-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS Novartis AG (CH) 2015-01-07 EP disclosed
WO-2014141038-A2 MARKERS ASSOCIATED WITH WNT INHIBITORS IRM LLC (BM) 2014-09-18 WO disclosed
US-20130310375-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2013-11-21 US disclosed
US-20130310375-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2013-11-21 US disclosed
EP-2403832-B1 N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2013-11-20 EP disclosed
US-8546396-B2 N-(hetero)aryl, 2-(hetero)aryl—substituted acetamides for use as Wnt signaling modulators IRM LLC (BM) 2013-10-01 US disclosed
US-8546396-B2 N-(hetero)aryl, 2-(hetero)aryl—substituted acetamides for use as Wnt signaling modulators IRM LLC (BM) 2013-10-01 US disclosed
WO-2013130364-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS NOVARTIS AG (CH) 2013-09-06 WO disclosed
EP-2623493-A1 N-(hetero)aryl,2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators IRM LLC (BM) 2013-08-07 EP disclosed
EP-2403832-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2012-01-11 EP disclosed
US-20110237573-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2011-09-29 US disclosed
US-20110237573-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2011-09-29 US disclosed
US-20110237573-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2011-09-29 US disclosed
WO-2010101849-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2010-09-10 WO disclosed
WO-2010101849-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2010-09-10 WO disclosed
WO-2010101849-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS IRM LLC (BM) 2010-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160024587-A1 MARKERS ASSOCIATED WITH WNT INHIBITORS WNT1, WNT3, WNT3A WNT3A 3/4885PORCN 2693/4885
US-20210128553-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY WNT1, CTNNB1, WNT3 WNT3A 4/4885PORCN 3182/4885
US-20130310375-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS WNT1, WNT3A, WNT3 WNT3A 2/4885PORCN 2618/4885
US-20150125857-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF Wnt SIGNALING INHIBITORS USING RNF43 MUTATION STATUS WNT3, WNT3A, DKK1 WNT3A 2/4885PORCN 2382/4885
US-20190203301-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS WNT3, WNT3A, DKK1 WNT3A 2/4885PORCN 2382/4885
US-20160082014-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS WNT1, CTNNB1, CTNNA1 WNT3A 4/4885PORCN 2988/4885
US-10251893-B2 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators WNT1, CTNNB1, CTNNA1 WNT3A 4/4885PORCN 2988/4885
US-10422007-B2 Markers associated with Wnt inhibitors WNT1, WNT3, WNT3A WNT3A 3/4885PORCN 2693/4885
US-20180153884-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY WNT1, CTNNB1, WNT3 WNT3A 4/4885PORCN 3182/4885
US-20180000832-A1 N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS WNT1, CTNNB1, CTNNA1 WNT3A 4/4885PORCN 2988/4885
US-20110237573-A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS WNT1, CTNNB1, WNT3A WNT3A 3/4885PORCN 2999/4885
US-20170306409-A1 CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS WNT3, WNT3A, DKK1 WNT3A 2/4885PORCN 2382/4885
US-20230201194-A1 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY WNT1, CTNNB1, WNT3 WNT3A 4/4885PORCN 3182/4885
US-20210054466-A1 TUMOR BIOMARKERS AND USE THEREOF CTNNB1, CTNNBL1, WNT1 WNT3A 9/4885PORCN 3611/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.