Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 19/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17233493 | 0.91 | TRPM8 (0.68) | TRPM8ALDH1A1POLB | |
| SCHEMBL2717592 | 0.90 | TRPM8 (1.00) | TRPM8ALDH1A1POLB | |
| SCHEMBL19892462 | 0.88 | TRPM8 (0.81) | TRPM8ALDH1A1POLB | |
| SCHEMBL17233492 | 0.85 | TRPM8 (0.68) | TRPM8 | |
| SCHEMBL17233498 | 0.84 | TRPM8 (0.74) | TRPM8 | |
| SCHEMBL17233501 | 0.84 | TRPM8 (0.59) | TRPM8ALDH1A1POLB | |
| SCHEMBL17928947 | 0.83 | TRPM8 (0.69) | TRPM8 | |
| SCHEMBL18202372 | 0.83 | TRPM8 (0.72) | TRPM8 | |
| SCHEMBL17928946 | 0.83 | TRPM8 (0.71) | TRPM8 | |
| SCHEMBL17233487 | 0.83 | TRPM8 (0.61) | TRPM8ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | Seaomyx, Inc. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | SENOMYX INC (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2016-11-03 | — | — | US | disclosed |
| US-9394287-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150313820-A1 | PREPARATIONS | SYMRISE AG (DE) | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | TRPM8 1/4885ALDH1A1 1409/4885POLB 4439/4885 |
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | TRPM8 1/4885ALDH1A1 1409/4885POLB 4439/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | TRPM8 97/4885ALDH1A1 1029/4885POLB 3252/4885 |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885ALDH1A1 3975/4885POLB 2854/4885 |
| US-20150313820-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | TRPM8 101/4885ALDH1A1 563/4885POLB 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.